Esophageal affection is a most common splanchnic lesion when systemic scleroderma starts to affect the digestive system. Most patients suffer from symptoms like dysphagia, heartburn, acid regurgitation, foods backflowing from stomach and esophagus, turgor or pain with the upper abdomen. In the late stage or no proper treatment for long, the patient may appear serious dystrophy or prostration, which has a strong impact on the living quality and prognosis. So far, there is no medicine of good efficacy and specificity for such a disease, but adjust posture and diets or give expectant treatment concerning clinical symptoms like applying protective agent of gastric mucosa, antihistamine or gastrointestinal digestion medicines.

To provide the patients of such disease an ideal Chinese medicine, a team led by Mr.Guo Gang, the Associate Chief Physician of Rheumatism and Immunity Department of Hebei Yiling Hospital obtained approval from Hebei Science and Technology Department and conducted an in-depth experiment and clinical research for TCM therapies of such disease on the basis of Hebei Yiling Medicine Group technical and hardware advantages. An analytical study of the clinical manifestations and pathogenesis shows that the esophageal affection caused by systemic scleroderma can be classified as the category of dysphagia per TCM theories, and the major pathogenesis is insufficiency of both the spleen and the kidney functions as the principal aspect and retardation caused by stagnation of Qi and stagnant blood as the secondary aspect. Based on this conclusion, Mr.Guo Gang and et al determined the treatment principles of warming yang, supplementing Qi, improving digestion，softening and resolving hard masses, regulating the flow of qi and regulating the meridians. Accordingly and referring to proven TCM prescriptions, they have successfully developed Shenzhe Zhuyun Mixture for treatment of esophageal affection caused by systemic scleroderma with strict preparation technology and quality standards.

An experimental study indicates that three dosage of Shenzhe Zhuyun Mixture will be able to promote mouse's gastricemptying and small intestine's peristalsis as well as reduce inhibition to small intestine peristalsis by L-Ephedrine evidently， of which the effect is equivalent to Motilium(Domperidone), able to improve the pH value at the mucous membrane of the lower end of esophagus.

Clinical researches indicate that Shenzhe Zhuyun Mixture's functions are evident in relieving the symptoms of esophageal affection, reducing the transit time of barium agent through esophagus in standing or lying position, improving the emptying index of barium agent in lying position and enhancing the peristalsis function of esophagus; meanwhile, it can improve patients' survival quality. In treatment of esophageal affection caused by systemic scleroderma, the overall effective rate is 96.88% with basic cure rate of 3.13%, apparent rate of 50% and effective rate of 43.75% without any toxicity or side effect found. It can be concluded that Shenzhe Zhuyun Mixture is an effective and relatively ideal Chinese medicine product in treatment of esophageal affection caused by systemic scleroderma.

Furthermore, in the study Mr.Guo Gang and et al created a sophisticated and distinct procedure of X-ray barium meal examination initiatively in China based on patients' clinical symptoms, dynamic changes and 100 normal people's emptying time of barium agent, which can provide objective indicators for clinical applications. Meanwhile, they determined the standard value of barium agent's emptying time of normal person who is in lying position.